How does Ozempic work?
Author: Oksana Aron, MD Source: Weight Loss NYC Oct 6, 2025Semaglutide and Weight Loss
Ozempic acts like a hormone that comes from your digestive tract called glucagon-like peptide (GLP-1), [which] helps lower blood sugar and creates a feeling of fullness… This can change how your body responds to food and [thus] isn’t signaling the need to eat in order to maintain your usual weight…
In recent years, the FDA has approved several new weight loss injections that are approved for long-term use. Whereas Ozempic is available for diabetics, similar drugs have been produced that operate under similar principles.
- Wegovy is approved for weight loss, using a different dosing strategy of semaglutide, since 2021.
- Mounjaro and Zepbound utilize tirzepatide, operating under similar principle, since 2023.
- Saxenda has been available since 2014.
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Phentermine stimulates the central nervous system to suppress appetite. Qsymia is a combination of Phentermine to suppress appetite, with Topiramate acting to decrease appetite and increase feelings of fullness. Diethylpropion and Phendimetrazine are sympathomimetic amines, stimulating the central nervous system to suppress appetite.

…Ozempic contains a hormone called GLP-1 which aids in weight loss and reducing appetite by acting on specific areas of the brain responsible for hunger and satiety. GLP-1 also slows the gastric emptying which further adds to the feeling of fullness and many report a reduced desire to eat.
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Dr. Aron is a medical physician and medical weight loss expert specialist: For several decades she has helped thousands of New Yorkers lose tons of weight in months, not years.
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