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How Wegovy affects appetite

Author: Oksana Aron, MD Source: Weight Loss NYC Oct 31, 2025

Semaglutide for weight loss

The active ingredient of Wegovy is semaglutide, which reduces appetite by mimicking the action of a natural hormone called “glucagon-like peptide-1” or GLP-1, an appetite hormone made primarily in your digestive tract that targets areas of the brain to regulate appetite after eating. Its action reduces appetite and induces insulin.

Studies showed with continued use, about 77% of patients had lost weight and keep it off for over two years. On average, patients lost about 15% of their weight after 2 years time.

Wegovy affects the GLP-1 receptor in the brain that regulates appetite, and slows how quickly the stomach empties, which makes you feel fuller for longer. It also enhances the production of insulin.

You can lose weight because you will typically eat less and feel fuller when you do eat. This and similar treatments are available for long-term use if effective for you, but must use it in addition to a healthy diet and exercise to help promote weight loss.

Studies showed with continued use, about 77% of patients had lost weight and keep it off for over two years. On average, patients lost about 15% of their weight after 2 years time.

Discuss with Dr. Oksana Aron

This is not all you need to know about Wegovy (semaglutide) for safe and effective use and does not replace Dr Aron’s medical weight loss guidance. She will review your available options with you and provide personalized structured program to guide your way

Dr. Aron is a medical physician and medical weight loss expert specialist: For several decades she has helped thousands of New Yorkers lose tons of weight in months, not years.

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Start with medical expert weight loss physician Oksana Aron, M.D.

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Adapted from Drug Information Database

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